Which is a common side effect of ondansetron use?

Ondansetron is a selective serotonin 5-HT3 receptor antagonist commonly used to prevent nausea and vomiting associated with chemotherapy, radiotherapy, and surgery. One of the notable side effects of ondansetron is constipation, which can occur due to its action on the gastrointestinal system. By blocking serotonin receptors in the gut, ondansetron can slow down gastrointestinal motility, leading to a reduced frequency of bowel movements and potential constipation as a result.

Other side effects related to ondansetron are typically less common. For instance, while drowsiness can occur with some medications, ondansetron is generally not associated with sedation. Excitation is uncommon because ondansetron does not stimulate the nervous system in a way that would typically lead to such a side effect. Similarly, while dry mouth can occur with many medications, the incidence in ondansetron may not be as pronounced compared to other anticholinergic agents. Thus, constipation stands out as a characteristic and recognized side effect of ondansetron use.