What is a common side effect of ondansetron?

Ondansetron, a selective serotonin 5-HT3 receptor antagonist, is commonly used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. One notable side effect associated with ondansetron is headache. This can occur because the medication affects serotonin receptors in the central nervous system, and its impact on these pathways can lead to tension-type headaches or migraines in some patients.

Headaches are also a frequent side effect of many medications that modulate serotonin levels, reinforcing the link between ondansetron and this particular side effect. While other side effects, such as constipation, dry mouth, and fatigue, can occur, headaches stand out as a more commonly reported reaction in clinical studies and patient feedback when using ondansetron. Understanding this side effect is crucial for healthcare providers so they can manage and address patient needs effectively during treatment.