What is a common adverse effect of using metoclopramide for antiemetic therapy?

Metoclopramide is commonly associated with extrapyramidal symptoms as a notable adverse effect due to its mechanism of action. This drug works primarily as a dopamine receptor antagonist, particularly blocking D2 receptors in the central nervous system. This blockade can lead to disruptions in motor control, resulting in symptoms that resemble those seen in Parkinson's disease, such as tremors, rigidity, and involuntary muscle movements. These extrapyramidal symptoms are more likely to occur with higher doses and prolonged use, underscoring the importance of monitoring patients on metoclopramide therapy.

While other adverse effects can occur with metoclopramide, extrapyramidal symptoms are particularly significant and warrant attention as they can impact a patient's quality of life and may require additional treatment to manage.