How does patient age impact the administration of antiemetic agents?

Patient age significantly impacts the pharmacokinetics and pharmacodynamics of medications, including antiemetic agents. In elderly patients, physiological changes such as decreased liver and kidney function, altered body composition, and changes in receptor sensitivity can affect how drugs are metabolized and excreted. As a result, they often have an increased sensitivity to medications and may experience enhanced effects from standard doses.

Lower doses of antiemetic agents are often required for elderly patients to avoid adverse effects such as sedation, confusion, and dizziness, which can significantly affect their quality of life and increase the risk of falls and fractures. Careful consideration of these factors is crucial in tailoring appropriate treatment regimens for this population, making it imperative for healthcare providers to adjust dosing accordingly to ensure safety and efficacy.